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PIE Council
General Council Members V
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Craig S. Atwood Ph.D.
University of Western Australia, Perth
Associate Professor, Department of Medicine
Research Director, Wisconsin Alzheimer's Institute and Wisconsin Comprehensive Memory Program
Hormonal Regulation of Aging and Neurodegenerative Diseases
Research in my laboratory draws together my interests in reproductive endocrinology and neuroscience in order to examine experimentally the hormonal regulation of aging and Alzheimer's disease. The basic premise behind the research is that hormones that regulate reproduction in mammals act in an antagonistic pleiotrophic manner to control aging via cell cycle signaling; promoting growth and development early in life in order to achieve reproduction, but later in life, in a futile attempt to maintain reproduction, become dysregulated and drive senescence (Bowen and Atwood, 2004, Gerontology). To this end, we have demonstrated that the age-related increase in luteinizing hormone and decline in sex steroids is directly responsible, via mechanisms related to the aberrant re-entry of post-mitotic neurons into the cell cycle, for the age-related increase in the incidence of Alzheimer's disease. Recent data suggests similar mechanisms are responsible for stroke. A number of different animal (from C. elegans to humans) and in vitro (cell lines and primary cells) models are used to address how endocrine dyscrasia associated with menopause/andropause drives both aging and age-related diseases. Dr. Atwood's laboratory utilizes a variety of techniques including molecular biology (microarray technologies), histology, and protein (proteomics), lipid and oxidative chemistries in order to gain insights into these aging processes. Our research aims to identify and implement therapeutics to delay the onset or slow the progression of senescence and aging-related diseases like Alzheimer's disease through the manipulation of HPG axis hormones.
